Research the web site for the Harvard/MGH Middle on Genomics, Weak Populations, and Well being Disparities and also you’ll discover a few of what Bobak Seddighzadeh was as much as previous to beginning his research on the Kirk Kerkorian Faculty of Drugs at UNLV.
Bobak Seddighzadeh, is a analysis affiliate on the Harvard/MGH Middle of Genomics, Weak Populations and Well being Disparities. Throughout his graduate work at New York College’s Gallatin Faculty, he studied inhabitants and medical genetics and graduated because the valedictorian of his class. Since then, Seddighzadeh has centered his analysis on the intersection of genomics and well being inequity. Now, as venture director of the Jamaica Most cancers Care & Analysis Institute (JACCRI), his work consists of helping with the event of a potential prostate most cancers genetics research in Jamaican males and the institution of nationwide palliative care pointers for the Ministry of Well being of Jamaica.
Sure, Seddighzadeh, now set to graduate along with his MD in 2022, already holds a formidable resume. His analysis has appeared in peer-reviewed journals that embody: Epigenomics, BioMedicine, and European Urology. As a member of the medical college’s constitution class, he took time in between his second and third years of medical college to pursue further coaching in most cancers genomics in Dr. Franklin Huang’s lab on the College of California, San Francisco, a physician-scientist whom he met whereas at Harvard.
Addressing Vaccine Hesitancy
Whereas Seddighzadeh’s focus in Huang’s lab was on most cancers, through the top of the pandemic, Huang directed his lab’s consideration towards understanding COVID-19. “On the time, a pattern emerged that women and men contracted COVID at comparable charges, but males have been dying at better proportions relative to girls,” mentioned Seddighzadeh. “We investigated publicly obtainable genomic knowledge units of human lungs to see whether or not or not there have been intercourse variations between women and men lung cells that will clarify this phenomenon. Positive sufficient, we found that males had a better proportion of lung cells that expressed the receptors that COVID-19 requires to infiltrate our cells.”
Huang and Seddighzadeh additionally investigated the prostate to see if there’s potential for COVID-19 infiltration. “Surprisingly, we found that the prostate additionally possesses the receptor pairs wanted for COVID infiltration into the cell, albeit at very small quantities.”
Seddighzadeh stresses that rather more analysis must be executed earlier than the scientific implications of the analysis executed in Huang’s lab can come to gentle. As a part of his analysis capstone, Seddighzadeh, with Huang as his mentor, has designed a research to grasp the genetic underpinnings of aggressive prostate most cancers.
“I’m on an genuine journey to study all that I can,” mentioned Seddighzadeh, who acquired a full-tuition scholarship to Kerkorian Faculty of Drugs in 2017 courtesy of Dr. Barbara Atkinson, founding dean, and Maureen Schafer, the medical college’s former chief of workers. “I need to lead a lifetime of function and for me meaning making time to pursue significant initiatives which have nice potential to assist others by way of medication.”
Involved about vaccine hesitancy, Seddighzadeh has authored a chunk for Males’s Well being journal in regards to the security of mRNA COVID-19 vaccines. He additionally wrote a visitor column for the Las Vegas Solar, arguing that the advantages of the Johnson & Johnson vaccine far outweighed the dangers of blood clots.
A biology and biochemistry honors graduate of Loyola Marymount College in California, Seddighzadeh accomplished two years of well being disparities analysis at Charles R Drew/UCLA Medical Training Program previous to going to New York College (NYU) for graduate college. After he graduated from NYU, he acquired a job supply at Harvard from a famend researcher he met throughout graduate college, Dr. Alexandra E. Shields, director of the Harvard/MGH Middle of Genomics, Weak Populations, and Well being Disparities. At Harvard Medical Faculty, he helped examine how psychosocial stress modulates our stress circuit (also called your HPA-axis) to grasp the way it can affect continual illness.
“Dr. Shields had a grand imaginative and prescient of serving to to ascertain a world-class most cancers institute in Kingston, Jamaica,” mentioned Seddighzadeh. “She was impressed by their unusually excessive charges of most cancers mixed with their dramatic want for analysis and scientific capability. I had little doubt in my thoughts that this was an expertise that I wished to be a part of. I wished to contribute to the betterment of conquering most cancers, discover ways to construct organizations and start-ups, in addition to partake in a global expertise. I used to be employed by Dr. Shields to be the inaugural venture director of the most cancers institute and to maneuver to Kingston to assist her set up the institute from the bottom up. I maintained my position up till my first 12 months of medical college, after which I stepped all the way down to concentrate on my research.”
The most cancers heart in Jamaica is now funded by the Nationwide Institutes of Well being.
“I hope, ultimately or some type, to assist UNLV set up its personal world-class most cancers heart and analysis institute for town of Las Vegas,” mentioned Seddighzadeh, who believes the way forward for medication is in “precision medication,” or using one’s genetic make-up to tailor therapies to that particular person.
Seddighzadeh, who misplaced his father to pancreatic most cancers between his second and third years of medical college, mentioned the expertise with Dr. Shields and the most cancers heart “has given me the boldness to be a pacesetter in most cancers.”
His dad and mom immigrated from Iran to the U.S. to offer their kids higher alternatives in life. They moved from California to Las Vegas 4 years earlier than Seddighzadeh began medical college. “My father and mom have been the yin and yang of my growth. My father was a serial entrepreneur — very logical, meticulous, and hard-working. From him, I realized the worth of self-discipline and persistence. He instilled in me a progress mindset — that I can accomplish something that I select so long as I continue to learn, work laborious, and persist by way of setbacks. My mom was a scientific psychologist. She gave me values of ethics, simplicity, caring, and doing proper by others, and to be beneficiant. She instilled in me emotional intelligence and consciousness. I feel it’s the distinctive mixture of their abilities that has given me a basis to hopefully make strides as a fantastic physician for my sufferers and as a pacesetter for my neighborhood.”
Training was all the time burdened in Seddighzadeh’s household. “In center college, I keep in mind I practically introduced my mom to tears once I introduced dwelling a ‘B’ as a result of she knew that I used to be able to extra.”
Seddighzadeh’s favourite query rising up was “Why?”
“I keep in mind once I was 8 years outdated I wished to grasp how electrical energy works, so I learn a e-book referred to as, How Issues Work. The e-book defined bodily ideas and phenomenon of how numerous objects from gentle bulbs to nuclear bombs work. Within the seventh grade, I learn my sister’s highschool physics e-book through the summer time to raised perceive pure phenomena. Then in highschool, I learn books on diet, and I realized how the endocrine system and our well being are affected by our dietary selections.”
To today, the physician-scientist Seddighzadeh admires most is the late Dr. Jonas Salk. “I like Dr. Salk’s ambition for using his coaching as a doctor and scientist to discover a treatment for polio, after which serving to to launch probably the most profitable vaccine campaigns in historical past. Much more admirable was his determination to not patent the vaccine with a purpose to make it accessible to the world. I’m impressed by this mind, selflessness, and dedication to additional medication, and I hope to attain the identical sooner or later.”
He plans on finishing a residency in inner medication so he can pursue a fellowship that enables him to satisfy his dream of changing into a hematologist-oncologist. He mentioned his dad’s loss of life from pancreatic most cancers had a lot to do along with his alternative of medical specialty.
“I’ve been referred to as upon to grow to be a physician-scientist as a result of, presently, we want higher solutions for a lot of of our sufferers. For instance, mesothelioma, pancreatic most cancers, and mind cancers all have underneath 12 % five-year survival charges,” Seddighzadeh mentioned. “I need to use my scientific grounding to deal with my sufferers, their tales to encourage new analysis within the laboratory, and the findings of my analysis to assist heal my sufferers in more practical methods. The way forward for medication can solely advance if we proceed to select up and transfer the yardstick.”